Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides

Author:

Buscaill Pierre1ORCID,Chandrasekar Balakumaran1ORCID,Sanguankiattichai Nattapong1ORCID,Kourelis Jiorgos1ORCID,Kaschani Farnusch2,Thomas Emma L.1ORCID,Morimoto Kyoko1ORCID,Kaiser Markus2ORCID,Preston Gail M.1ORCID,Ichinose Yuki3ORCID,van der Hoorn Renier A. L.1

Affiliation:

1. Department of Plant Sciences, University of Oxford, Oxford, UK.

2. ZMB Chemical Biology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.

3. The Graduate School of Environmental and Life Science, Okayama University, Japan.

Abstract

Glycosylation goes back and forth Plants produce receptors that recognize fragments of microbial flagellin, thus monitoring for infection by bacteria. Buscaill et al. studied how a flagellin fragment is made accessible for recognition by host glycosidases, which degrade the glycosylations shielding the peptide that triggers the immune response. The pathogen, in turn, evades detection by altering flagellin glycosylation and inhibiting the host glycosidase. This aspect of plant defense against infection plays out in the apoplast, the extracellular space within plant tissues. Science , this issue p. eaav0748

Funder

Biotechnology and Biological Sciences Research Council

European Research Council

Royal Thai Government Scholarship

Clarendon Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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