Complete Genome Sequence and Lytic Phase Transcription Profile of a Coccolithovirus-Reference-Cited by-同舟云学术

Complete Genome Sequence and Lytic Phase Transcription Profile of a Coccolithovirus

Published:2005-08-12 Issue:5737 Volume:309 Page:1090-1092
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wilson William H.¹²³⁴,Schroeder Declan C.¹²³⁴,Allen Michael J.¹²³⁴,Holden Matthew T. G.¹²³⁴,Parkhill Julian¹²³⁴,Barrell Bart G.¹²³⁴,Churcher Carol¹²³⁴,Hamlin Nancy¹²³⁴,Mungall Karen¹²³⁴,Norbertczak Halina¹²³⁴,Quail Michael A.¹²³⁴,Price Claire¹²³⁴,Rabbinowitsch Ester¹²³⁴,Walker Danielle¹²³⁴,Craigon Marie¹²³⁴,Roy Douglas¹²³⁴,Ghazal Peter¹²³⁴

Affiliation:

1. Plymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth, PL1 3DH, UK.

2. Marine Biological Association, Citadel Hill, Plymouth, PL1 2PB, UK.

3. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

4. Scottish Centre for Genomic Technology and Informatics, Chancellor's Building, College of Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.

Abstract

The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi . Among the 472 predicted genes of the 407,339–base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

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