Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan-Reference-Cited by-同舟云学术

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

Published:2003-06-06 Issue:5625 Volume:300 Page:1584-1587
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Girardin Stephen E.¹²³⁴⁵,Boneca Ivo G.¹²³⁴⁵,Carneiro Leticia A. M.¹²³⁴⁵,Antignac Aude¹²³⁴⁵,Jéhanno Muguette¹²³⁴⁵,Viala Jérôme¹²³⁴⁵,Tedin Karsten¹²³⁴⁵,Taha Muhamed-Kheir¹²³⁴⁵,Labigne Agnès¹²³⁴⁵,Zäthringer Ulrich¹²³⁴⁵,Coyle Anthony J.¹²³⁴⁵,DiStefano Peter S.¹²³⁴⁵,Bertin John¹²³⁴⁵,Sansonetti Philippe J.¹²³⁴⁵,Philpott Dana J.¹²³⁴⁵

Affiliation:

1. Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Institut Pasteur, 28, Rue du Dr. Roux, 75724Paris Cedex 15, France.

2. Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28, Rue du Dr. Roux, 75724Paris Cedex 15, France.

3. Groupe d'Immunité Innée et Signalisation, Institut Pasteur, 28, Rue du Dr. Roux, 75724Paris Cedex 15, France.

4. Unité des Neisseria, Institut Pasteur, 28, Rue du Dr. Roux, 75724Paris Cedex 15, France.

5. Institut für Mikrobiologie und Tierseuchen, Freie Universität Berlin, Philippstrasse 13, D-10115 Berlin, Germany.

Abstract

Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod molecules remains largely uncharacterized. Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N -acetylglucosamine– N -acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-κB pathway. Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

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