Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice-Reference-Cited by-同舟云学术

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

Published:2016-11-18 Issue:6314 Volume:354 Page:904-908
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ittner Arne¹,Chua Sook Wern¹,Bertz Josefine¹,Volkerling Alexander¹,van der Hoven Julia¹,Gladbach Amadeus¹,Przybyla Magdalena¹,Bi Mian¹,van Hummel Annika¹²,Stevens Claire H.¹,Ippati Stefania¹,Suh Lisa S.¹³,Macmillan Alexander⁴,Sutherland Greg³,Kril Jillian J.³,Silva Ana P. G.⁵,Mackay Joel P.⁵,Poljak Anne⁶,Delerue Fabien¹⁷,Ke Yazi D.²,Ittner Lars M.¹⁷⁸

Affiliation:

1. Dementia Research Unit, School of Medical Sciences, University of New South Wales (UNSW), Sydney, New South Wales 2052, Australia.

2. Motor Neuron Disease Unit, School of Medical Sciences, UNSW, Sydney, New South Wales 2052, Australia.

3. Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney, New South Wales 2050, Australia.

4. Biomedical Imaging Facility, Mark Wainwright Analytical Centre, UNSW, Sydney, New South Wales 2052, Australia.

5. School of Molecular Bioscience, University of Sydney, Sydney, New South Wales 2050, Australia.

6. Biomedical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW, Sydney, New South Wales 2052, Australia.

7. Transgenic Animal Unit, Mark Wainwright Analytical Centre, UNSW, Sydney, New South Wales 2052, Australia.

8. Neuroscience Research Australia, Sydney, New South Wales 2031, Australia.

Abstract

Tau phosphorylation—not all bad Alzheimer's disease presents with amyloid-β (Aβ) plaques and tau tangles. The prevailing idea in the field is that Aβ induces phosphorylation of tau, which in turn mediates neuronal dysfunction. Working in Alzheimer's disease mouse models, Ittner et al. found evidence for a protective role of tau in early Alzheimer's disease. This protection involves specific tau phosphorylation at threonine 205 at the postsynapse. A protective role of phosphorylated tau in disease challenges the dogma that tau phosphorylation only mediates toxic processes. Science , this issue p. 904

Funder

National Health and Medical Research Council

Australian Research Council

Alzheimer's Association

Alzheimer's Australia

NIH

UNSW Australia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference53 articles.