Influence of Gene Action Across Different Time Scales on Behavior-Reference-Cited by-同舟云学术

Influence of Gene Action Across Different Time Scales on Behavior

Published:2002-04-26 Issue:5568 Volume:296 Page:741-744
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ben-Shahar Y.¹,Robichon A.²,Sokolowski M. B.³,Robinson G. E.¹⁴

Affiliation:

1. Department of Entomology,

2. CESG/CNRS, Université de Bourgogne, 15 rue Hugues Picardet, Dijon 21000, France.

3. Department of Zoology, University of Toronto, 3359 Mississauga Road, Mississauga, Ontario L5L1C6, Canada.

4. Neuroscience Program, University of Illinois at Urbana-Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA.

Abstract

Genes can affect natural behavioral variation in different ways. Allelic variation causes alternative behavioral phenotypes, whereas changes in gene expression can influence the initiation of behavior at different ages. We show that the age-related transition by honey bees from hive work to foraging is associated with an increase in the expression of the foraging ( for ) gene, which encodes a guanosine 3′,5′-monophosphate (cGMP)–dependent protein kinase (PKG). cGMP treatment elevated PKG activity and caused foraging behavior. Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Natural Behavior Polymorphism Due to a cGMP-Dependent Protein Kinase of Drosophila

2. Evolution of foraging behavior in Drosophila by density-dependent selection

3. G. E. Robinson Am. Nat. in press.

4. T. D. Seeley Wisdom of the Hive (Harvard Univ. Press Cambridge MA 1997).

5. We used RT-PCR to isolate a fragment of the honey bee for ortholog Amfor. Total RNA was isolated from five whole bees (TRizol Invitrogen). RT (1 μg of total RNA) was performed with polyT (18) primer and Superscript II reverse transcriptase (Gibco BRL). PCR was done with degenerate primers designed to amplify fragments corresponding to amino acids 165 to 472 of Amfor (covering conserved cGMP binding and kinase domains). The full coding sequence of Amfor (GenBank accession number ) was obtained by probing a honey bee brain cDNA library with the positive PCR fragment. Overall similarity to Drosophila for ( dg2 ) 87%; Drosophila dg1 70%; mammalian pkg1 73%; Caenorhabditis elegans pkg 70%.

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