Role of Sensory-Evoked NMDA Plateau Potentials in the Initiation of Locomotion

Author:

Di Prisco Gonzalo Viana12,Pearlstein Edouard12,Robitaille Richard12,Dubuc Réjean12

Affiliation:

1. G. Viana Di Prisco, E. Pearlstein, R. Robitaille, Département de Physiologie, Centre de Recherche en Sciences Neurologiques, Université de Montréal, C.P. 6128, succursale Centre-Ville, Montréal, Québec, Canada, H3C 3J7.

2. R. Dubuc, Département de Kinanthropologie, Université du Québec à Montréal, Montréal, C.P. 8888, succursale Centre-Ville, Québec, Canada, H3C 3P8 and Département de Physiologie, Centre de Recherche en Sciences Neurologiques, Université de Montréal, C.P. 6128, succursale Centre-Ville, Montréal, Québec, Canada, H3C 3J7.

Abstract

Reticulospinal (RS) neurons constitute the main descending motor system of lampreys. This study reports on natural conditions whereby N -methyl- d -aspartate (NMDA)–mediated plateau potentials were elicited and associated with the onset of locomotion. Reticulospinal neurons responded in a linear fashion to mild skin stimulation. With stronger stimuli, large depolarizing plateaus with spiking activity were elicited and were accompanied by swimming movements. Calcium imaging revealed sustained intracellular calcium rise upon sensory stimulation. Blocking NMDA receptors on RS neurons prevented the plateau potentials as well as the associated rise in intracellular calcium. Thus, the activation of NMDA receptors mediates a switch from sensory-reception mode to a motor command mode in RS neurons.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Cited by 114 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3