Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus-Reference-Cited by-同舟云学术

Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus

Published:2004-03-19 Issue:5665 Volume:303 Page:1866-1870
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Stevens James¹²³⁴,Corper Adam L.¹²³⁴,Basler Christopher F.¹²³⁴,Taubenberger Jeffery K.¹²³⁴,Palese Peter¹²³⁴,Wilson Ian A.¹²³⁴

Affiliation:

1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

3. Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.

4. Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC 20306, USA.

Abstract

The 1918 “Spanish” influenza pandemic represents the largest recorded outbreak of any infectious disease. The crystal structure of the uncleaved precursor of the major surface antigen of the extinct 1918 virus was determined at 3.0 angstrom resolution after reassembly of the hemagglutinin gene from viral RNA fragments preserved in 1918 formalin-fixed lung tissues. A narrow avian-like receptor-binding site, two previously unobserved histidine patches, and a less exposed surface loop at the cleavage site that activates viral membrane fusion reveal structural features primarily found in avian viruses, which may have contributed to the extraordinarily high infectivity and mortality rates observed during 1918.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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