Pou5f1 Transcription Factor Controls Zygotic Gene Activation In Vertebrates-Reference-Cited by-同舟云学术

Pou5f1 Transcription Factor Controls Zygotic Gene Activation In Vertebrates

Published:2013-08-30 Issue:6149 Volume:341 Page:1005-1009
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Leichsenring Manuel¹,Maes Julia¹,Mössner Rebecca¹,Driever Wolfgang¹²,Onichtchouk Daria¹²

Affiliation:

1. Developmental Biology Unit, Institute Biology I, Faculty of Biology, Albert-Ludwigs-University, 79085 Freiburg, Germany.

2. Center for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University, 79085 Freiburg, Germany.

Abstract

Pluripotency Control The transcription factors Pou5f1/Oct4, Sox2, and Nanog play central roles in pluripotency control in mammalian embryonic stem (ES) cells. The evolution of the pluripotency regulatory network and its roles during early development of nonmammalian vertebrates is unknown. Leichsenring et al. (p. 1005 , published online 15 August) show that in zebrafish embryos, Pou5f1 controls priming and transcriptional activation of the first zygotically expressed genes. This mechanism for transition from the transcriptionally silent cleavage stage to the transcriptionally active blastula stage may have evolved to control the prolonged cell pluripotency state in mammalian early development and ES cells, establishing a link between zygotic gene activation and pluripotency control.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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