Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding-Reference-Cited by-同舟云学术

Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding

Published:2015-04-10 Issue:6231 Volume:348 Page:242-245
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Xue Yali¹,Prado-Martinez Javier²,Sudmant Peter H.³,Narasimhan Vagheesh¹⁴,Ayub Qasim¹,Szpak Michal¹,Frandsen Peter⁵,Chen Yuan¹,Yngvadottir Bryndis¹,Cooper David N.⁶,de Manuel Marc²,Hernandez-Rodriguez Jessica²,Lobon Irene²,Siegismund Hans R.⁵,Pagani Luca¹⁷,Quail Michael A.¹,Hvilsom Christina⁸,Mudakikwa Antoine⁹,Eichler Evan E.³¹⁰,Cranfield Michael R.¹¹,Marques-Bonet Tomas²¹²,Tyler-Smith Chris¹,Scally Aylwyn¹³

Affiliation:

1. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.

2. ICREA at Institut de Biologia Evolutiva (CSIC/UPF), Parque de Investigación Biomédica de Barcelona (PRBB), Barcelona, Catalonia 08003, Spain.

3. Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

4. Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK.

5. Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

6. Institute of Medical Genetics, Cardiff University, Cardiff CF14 4XN, UK.

7. Department of Biological, Geological and Environmental Sciences, University of Bologna, 40134 Bologna, Italy.

8. Research and Conservation, Copenhagen Zoo, DK-2000 Frederiksberg, Denmark.

9. Rwanda Development Board, KG 9 Avenue, Kigali, Rwanda.

10. Howard Hughes Medical Institute, Seattle, WA 91895, USA.

11. Gorilla Doctors, Karen C. Drayer Wildlife Health Center, University of California, Davis, CA 95616, USA.

12. Centro Nacional de Análisis Genómico (Parc Cientific de Barcelona), Baldiri Reixac 4, 08028 Barcelona, Spain.

13. Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.

Abstract

Genomes in the mist The mountain gorilla is an iconic species that is at high risk of extinction. Xue et al. have sequenced 13 gorillas from two different populations to probe their genetic diversity. The genomes show large tracts of homozygosity and the loss of highly deleterious genetic variants, indicating population bottlenecks and inbreeding. This loss of genetic diversity appears to have started over 20,000 years ago and may have been caused by changes in climate and human-associated effects. Science , this issue p. 242

Funder

NIH

Howard Hughes Medical Institute

Wellcome Trust

European Research Council

Royal Society

Ministerio de Ciencia e Innovacion

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference61 articles.