Molecular Evolution of Protein Atomic Composition

Author:

Baudouin-Cornu Peggy1,Surdin-Kerjan Yolande1,Marlière Philippe2,Thomas Dominique1

Affiliation:

1. Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, 91 198 Gif-sur-Yvette Cedex, France.

2. Evologic SA, 4 rue Pierre Fontaine, 91000 Evry, France.

Abstract

Living organisms encounter various growth conditions in their habitats, raising the question of whether ecological fluctuations could alter biological macromolecules. The advent of complete genome sequences and the characterization of whole metabolic pathways allowed us to search for such ecological imprints. Significant correlations between atomic composition and metabolic function were found in sulfur- and carbon-assimilatory enzymes, which appear depleted in sulfur and carbon, respectively, in both the bacterium Escherichia coli and the eukaryote Saccharomyces cerevisiae . In addition to genetic instructions, genomic data thus also provide paleontological records of environmental nutrient availability and of metabolic costs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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