Repression of c- myc Transcription by Blimp-1, an Inducer of Terminal B Cell Differentiation-Reference-Cited by-同舟云学术

Repression of c- myc Transcription by Blimp-1, an Inducer of Terminal B Cell Differentiation

Published:1997-04-25 Issue:5312 Volume:276 Page:596-599
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lin Yi¹²³,Wong Kwok-kin¹²³,Calame Kathryn¹²³

Affiliation:

1. Y. Lin, Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

2. K. Wong, Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

3. K. Calame, Department of Microbiology and the Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Abstract

Transcription of c- myc in plasma cells, which are terminally differentiated B cells, is repressed by plasmacytoma repressor factor. This factor was identified as Blimp-1, known for its ability to induce B cell differentiation. Blimp-1 repressed c- myc promoter activity in a binding site–dependent manner. Treatment of BCL 1 lymphoma cells with interleukin-2 (IL-2) plus IL-5 induced Blimp-1 and caused a subsequent decline in c-Myc protein. Ectopic expression of Blimp-1 in Abelson-transformed precursor B cells repressed endogenous c-Myc and caused apoptosis; Blimp-1–induced death was partially overcome by ectopic expression of c-Myc. Thus, repression of c- myc is a component of the Blimp-1 program of terminal B cell differentiation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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