Transcriptional diversity during lineage commitment of human blood progenitors-Reference-Cited by-同舟云学术

Transcriptional diversity during lineage commitment of human blood progenitors

Published:2014-09-26 Issue:6204 Volume:345 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chen Lu¹²³,Kostadima Myrto²³⁴,Martens Joost H. A.⁵,Canu Giovanni²³,Garcia Sara P.²³,Turro Ernest²³,Downes Kate²³,Macaulay Iain C.⁶,Bielczyk-Maczynska Ewa²³,Coe Sophia²³,Farrow Samantha²³,Poudel Pawan²³,Burden Frances²³,Jansen Sjoert B. G.²³,Astle William J.²³⁷,Attwood Antony²³,Bariana Tadbir⁸⁹,de Bono Bernard¹⁰¹¹,Breschi Alessandra¹²,Chambers John C.¹³¹⁴,Choudry Fizzah A.²³,Clarke Laura⁴,Coupland Paul¹,van der Ent Martijn⁵,Erber Wendy N.¹⁵,Jansen Joop H.¹⁶,Favier Rémi¹⁷,Fenech Matthew E.¹⁸,Foad Nicola²³,Freson Kathleen¹⁹,van Geet Chris¹⁹,Gomez Keith⁹,Guigo Roderic¹²,Hampshire Daniel²³,Kelly Anne M.²³²⁰,Kerstens Hindrik H. D.⁵,Kooner Jaspal S.¹³¹⁴,Laffan Michael²¹,Lentaigne Claire²¹,Labalette Charlotte²³,Martin Tiphaine²³²²,Meacham Stuart²³,Mumford Andrew²³,Nürnberg Sylvia T.²³,Palumbo Emilio¹²,van der Reijden Bert A.¹⁶,Richardson David⁴,Sammut Stephen J.²⁴²⁵,Slodkowicz Greg⁴,Tamuri Asif U.⁴,Vasquez Louella³,Voss Katrin²³,Watt Stephen³,Westbury Sarah²⁶,Flicek Paul¹⁴,Loos Remco⁴,Goldman Nick⁴,Bertone Paul⁴²⁷²⁸,Read Randy J.²⁹,Richardson Sylvia⁷,Cvejic Ana¹²,Soranzo Nicole¹²,Ouwehand Willem H.¹²³,Stunnenberg Hendrik G.⁵,Frontini Mattia²³,Rendon Augusto²³⁷,

Affiliation:

1. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

2. Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.

3. National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.

4. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

5. Department of Molecular Biology, Radboud University, 6525 GA Nijmegen, Netherlands.

6. Sanger Institute–EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

7. Medical Research Council Biostatistics Unit, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK.

8. Department of Haematology, University College London Cancer Institute, London WC1E 6DD, UK.

9. The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free NHS Trust, London NW3 2QG, UK.

10. CHIME Institute, University College London, Archway Campus, London NW1 2DA, UK.

11. Auckland Bioengineering Institute, University of Auckland, Auckland 1010, New Zealand.

12. Centre for Genomic Regulation and University Pompeu Fabra, 08002 Barcelona, Spain.

13. Imperial College Healthcare NHS Trust, DuCane Road, London W12 0HS, UK.

14. Ealing Hospital NHS Trust, Southall, Middlesex UB1 3HW, UK.

15. Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia.

16. Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

17. Assistance Publique–Hopitaux de Paris, INSERM U1009, 94805 Villejuif, France.

18. Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.

19. Center for Molecular and Vascular Biology, University of Leuven, 3000 Leuven, Belgium.

20. Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge B2 0QQ, UK.

21. Department of Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London, London W12 0HS, UK.

22. Department of Twin Research & Genetic Epidemiology, Genetics and Molecular Medicine Division, St Thomas’ Hospital, King’s College, London SE1 7EH, UK.

23. School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK.

24. Department of Oncology, Addenbrooke’s Cambridge University Hospital NHS Trust, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK.

25. Cancer Research UK, Cambridge Institute, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK.

26. School of Clinical Sciences, University of Bristol, Bristol BS2 8DZ, UK.

27. Genome Biology and Developmental Biology Units, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

28. Wellcome Trust—Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK.

29. Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.

Abstract

A BLUEPRINT of immune cell development To determine the epigenetic mechanisms that direct blood cells to develop into the many components of our immune system, the BLUEPRINT consortium examined the regulation of DNA and RNA transcription to dissect the molecular traits that govern blood cell differentiation. By inducing immune responses, Saeed et al. document the epigenetic changes in the genome that underlie immune cell differentiation. Cheng et al. demonstrate that trained monocytes are highly dependent on the breakdown of sugars in the presence of oxygen, which allows cells to produce the energy needed to mount an immune response. Chen et al. examine RNA transcripts and find that specific cell lineages use RNA transcripts of different length and composition (isoforms) to form proteins. Together, the studies reveal how epigenetic effects can drive the development of blood cells involved in the immune system. Science , this issue 10.1126/science.1251086 , 10.1126/science.1250684 , 10.1126/science.1251033

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference88 articles.

1. Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

2. Concise Review: Sowing the Seeds of a Fruitful Harvest: Hematopoietic Stem Cell Mobilization

3. Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells

4. Self-Renewal Versus Differentiation in Hematopoietic Stem and Progenitor Cells: A Focus on Asymmetric Cell Divisions

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