Shulin packages axonemal outer dynein arms for ciliary targeting-Reference-Cited by-同舟云学术

Shulin packages axonemal outer dynein arms for ciliary targeting

Published:2021-02-26 Issue:6532 Volume:371 Page:910-916
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mali Girish R.¹^ORCID,Ali Ferdos Abid¹^ORCID,Lau Clinton K.¹^ORCID,Begum Farida¹,Boulanger Jérôme¹^ORCID,Howe Jonathan D.¹^ORCID,Chen Zhuo A.²^ORCID,Rappsilber Juri²³^ORCID,Skehel Mark¹^ORCID,Carter Andrew P.¹^ORCID

Affiliation:

1. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

2. Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany.

3. Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.

Abstract

Ciliary motors locked closed by Shulin Motile cilia and flagella are vital cellular organelles with functions that include setting up the left-right body axis, clearing airways of mucus, and driving single-cell movements. Cilia beating is powered by arrays of dynein motors, the key force generators being the outer dynein arm (ODA) complexes. Using the protozoan Tetrahymena , Mali et al. identified a factor, which they name Shulin, that binds newly synthesized ODAs. Cryo–electron microscopy revealed how Shulin locks the dynein motors together by shutting off motor activity and facilitating delivery of ODAs from the cytoplasm to their final position in the cilia. Science , this issue p. 910

Funder

Wellcome

Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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