Photons Add Up to Better Microscopy

Abstract

A new microscopy technique may open new vistas for researchers who want to peer into living cells. On page 530 , a research team from Cornell University describes how they used the additive energies of multiple photons to excite fluorescence from molecules that previously couldn't be observed with damaging or killing cells. In the current work, the researchers measured serotonin concentrations in living cells, but the technique should have a much broader application than that.