Affiliation:
1. Division of Biology 147-75, California Institute of Technology, Pasadena, CA 91125, USA.
Abstract
Heterotrimeric GTP-binding proteins (G proteins) participate in cellular signaling and regulate a variety of physiological processes. Disruption of the gene encoding the G protein subunit α
13
(Gα
13
) in mice impaired the ability of endothelial cells to develop into an organized vascular system, resulting in intrauterine death. In addition, Gα
13
(−/−) embryonic fibroblasts showed greatly impaired migratory responses to thrombin. These results demonstrate that Gα
13
participates in the regulation of cell movement in response to specific ligands, as well as in developmental angiogenesis.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
312 articles.
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