Parallel adaptation of rabbit populations to myxoma virus

Author:

Alves Joel M.123ORCID,Carneiro Miguel24ORCID,Cheng Jade Y.56,Lemos de Matos Ana7ORCID,Rahman Masmudur M.7,Loog Liisa38ORCID,Campos Paula F.69,Wales Nathan61011ORCID,Eriksson Anders12ORCID,Manica Andrea13ORCID,Strive Tanja1415ORCID,Graham Stephen C.16ORCID,Afonso Sandra2ORCID,Bell Diana J.17,Belmont Laura7,Day Jonathan P.1,Fuller Susan J.18ORCID,Marchandeau Stéphane19,Palmer William J.20,Queney Guillaume21ORCID,Surridge Alison K.17,Vieira Filipe G.6ORCID,McFadden Grant7,Nielsen Rasmus56ORCID,Gilbert M. Thomas P.622ORCID,Esteves Pedro J.223,Ferrand Nuno2424ORCID,Jiggins Francis M.1ORCID

Affiliation:

1. Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.

2. CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal.

3. Palaeogenomics and Bio-Archaeology Research Network Research Laboratory for Archaeology and History of Art, University of Oxford, Dyson Perrins Building, South Parks Road, Oxford OX1 3QY, UK.

4. Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, 4169-007 Porto, Portugal.

5. Departments of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA 94720, USA.

6. Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen 1350, Denmark.

7. The Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ 85287-5401, USA.

8. Manchester Institute of Biotechnology, School of Earth and Environmental Sciences, University of Manchester, Manchester M1 7DN, UK.

9. CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.

10. Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkeley, CA 94720, USA.

11. Department of Archaeology, University of York, King’s Manor, York YO1 7EP, UK.

12. Department of Medical and Molecular Genetics, King’s College London, London SE1 9RT, UK.

13. Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

14. Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.

15. Centre for Invasive Species Solutions, University of Canberra, Bruce, ACT 2601, Australia.

16. Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.

17. Centre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.

18. School of Earth, Environmental and Biological Sciences, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Australia.

19. Office National de la Chasse et de la Faune Sauvage, Nantes, France.

20. The Genome Center and Department of Plant Sciences, University of California, Davis, CA 95616, USA.

21. ANTAGENE, Wildlife Genetics Laboratory, La Tour de Salvagny (Lyon), France.

22. Norwegian University of Science and Technology, University Museum, 7491 Trondheim, Norway.

23. Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (CESPU), Gandra, Portugal.

24. Department of Zoology, Faculty of Sciences, University of Johannesburg, Auckland Park 2006, South Africa.

Abstract

Locating myxomatosis resistance Myxomatosis is a viral infection that was deliberately introduced from American cottontail rabbits into European rabbit populations to control their population. Over the past 60 years or so, similar resistance variants have emerged in parallel in the United Kingdom, France, and Australia. Alves et al. discovered that the basis for this resistance is polygenic, with selection converging on several host immunity and proviral alleles (see the Perspective by Miller and Metcalf). Interestingly, it now seems that the virus is counterevolving immune suppressive traits. Science , this issue p. 1319 ; see also p. 1277

Funder

National Institutes of Health

European Research Council

Wellcome Trust and the Royal Society

Programa Operacional Potencial Humano–Quadro de Referência Estratégica Nacional funds from the European Social Fund and Portuguese Ministério da Ciência, Tecnologia e Ensino Superior

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. F. Fenner F. N. Ratcliffe Myxomatosis (Cambridge Univ. Press 1965).

2. F. Fenner B. Fantini Biological Control of Vertebrate Pests: The History of Myxomatosis - an Experiment in Evolution (CABI 1999).

3. The development of genetic resistance to myxomatosis in wild rabbits in Britain

4. F. Fenner J. Ross in The European Rabbit: The History and Biology of a Successful Colonizer H. V. Thompson C. M. King Eds. (Oxford Univ. Press 1994) pp. 205–239.

5. Studies in the epidemiology of infectious myxomatosis of rabbits: V. Changes in the innate resistance of Australian Wild rabbits exposed to myxomatosis

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