A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses-Reference-Cited by-同舟云学术

A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

Published:2005-01-07 Issue:5706 Volume:307 Page:82-86
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hall Neil¹²³⁴⁵,Karras Marianna¹²³⁴⁵,Raine J. Dale¹²³⁴⁵,Carlton Jane M.¹²³⁴⁵,Kooij Taco W. A.¹²³⁴⁵,Berriman Matthew¹²³⁴⁵,Florens Laurence¹²³⁴⁵,Janssen Christoph S.¹²³⁴⁵,Pain Arnab¹²³⁴⁵,Christophides Georges K.¹²³⁴⁵,James Keith¹²³⁴⁵,Rutherford Kim¹²³⁴⁵,Harris Barbara¹²³⁴⁵,Harris David¹²³⁴⁵,Churcher Carol¹²³⁴⁵,Quail Michael A.¹²³⁴⁵,Ormond Doug¹²³⁴⁵,Doggett Jon¹²³⁴⁵,Trueman Holly E.¹²³⁴⁵,Mendoza Jacqui¹²³⁴⁵,Bidwell Shelby L.¹²³⁴⁵,Rajandream Marie-Adele¹²³⁴⁵,Carucci Daniel J.¹²³⁴⁵,Yates John R.¹²³⁴⁵,Kafatos Fotis C.¹²³⁴⁵,Janse Chris J.¹²³⁴⁵,Barrell Bart¹²³⁴⁵,Turner C. Michael R.¹²³⁴⁵,Waters Andrew P.¹²³⁴⁵,Sinden Robert E.¹²³⁴⁵

Affiliation:

1. Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

2. Department of Parasitology, Malaria Group, Leiden University Medical Center, Netherlands.

3. Immunology and Infection Section, Department of Biological Sciences, Imperial College London, Sir Alexander Fleming Building, Imperial College Road, London SW7 2AZ, UK.

4. The Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.

5. Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.

Abstract

Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage-specific selective pressures. Four strategies for gene expression are apparent during the parasites' life cycle: (i) housekeeping; (ii) host-related; (iii) strategy-specific related to invasion, asexual replication, and sexual development; and (iv) stage-specific. We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

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2. Genome sequence of the human malaria parasite Plasmodium falciparum

3. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

4. Materials and methods are available as supporting material on Science Online.

5. An efficient algorithm for large-scale detection of protein families

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