The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans-Reference-Cited by-同舟云学术

The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans

Published:2005-02-25 Issue:5713 Volume:307 Page:1321-1324
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Loftus Brendan J.¹²³⁴⁵,Fung Eula¹²³⁴⁵,Roncaglia Paola¹²³⁴⁵,Rowley Don¹²³⁴⁵,Amedeo Paolo¹²³⁴⁵,Bruno Dan¹²³⁴⁵,Vamathevan Jessica¹²³⁴⁵,Miranda Molly¹²³⁴⁵,Anderson Iain J.¹²³⁴⁵,Fraser James A.¹²³⁴⁵,Allen Jonathan E.¹²³⁴⁵,Bosdet Ian E.¹²³⁴⁵,Brent Michael R.¹²³⁴⁵,Chiu Readman¹²³⁴⁵,Doering Tamara L.¹²³⁴⁵,Donlin Maureen J.¹²³⁴⁵,D'Souza Cletus A.¹²³⁴⁵,Fox Deborah S.¹²³⁴⁵,Grinberg Viktoriya¹²³⁴⁵,Fu Jianmin¹²³⁴⁵,Fukushima Marilyn¹²³⁴⁵,Haas Brian J.¹²³⁴⁵,Huang James C.¹²³⁴⁵,Janbon Guilhem¹²³⁴⁵,Jones Steven J. M.¹²³⁴⁵,Koo Hean L.¹²³⁴⁵,Krzywinski Martin I.¹²³⁴⁵,Kwon-Chung June K.¹²³⁴⁵,Lengeler Klaus B.¹²³⁴⁵,Maiti Rama¹²³⁴⁵,Marra Marco A.¹²³⁴⁵,Marra Robert E.¹²³⁴⁵,Mathewson Carrie A.¹²³⁴⁵,Mitchell Thomas G.¹²³⁴⁵,Pertea Mihaela¹²³⁴⁵,Riggs Florenta R.¹²³⁴⁵,Salzberg Steven L.¹²³⁴⁵,Schein Jacqueline E.¹²³⁴⁵,Shvartsbeyn Alla¹²³⁴⁵,Shin Heesun¹²³⁴⁵,Shumway Martin¹²³⁴⁵,Specht Charles A.¹²³⁴⁵,Suh Bernard B.¹²³⁴⁵,Tenney Aaron¹²³⁴⁵,Utterback Terry R.¹²³⁴⁵,Wickes Brian L.¹²³⁴⁵,Wortman Jennifer R.¹²³⁴⁵,Wye Natasja H.¹²³⁴⁵,Kronstad James W.¹²³⁴⁵,Lodge Jennifer K.¹²³⁴⁵,Heitman Joseph¹²³⁴⁵,Davis Ronald W.¹²³⁴⁵,Fraser Claire M.¹²³⁴⁵,Hyman Richard W.¹²³⁴⁵

Affiliation:

1. The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.

2. Stanford Genome Technology Center, Stanford University, 855 California Avenue, Palo Alto, CA 94304, USA.

3. Neurobiology Sector, International School for Advanced Studies (SISSA-ISAS), Via Beirut 2-4, 34014 Trieste, Italy.

4. Department of Molecular Genetics and Microbiology, Duke University Medical Center, 322 CARL Building, Research Drive, Box 3546, DUMC, Durham, NC 27710, USA.

5. Genome Sciences Centre, 100-570 West 7th Avenue, Vancouver, BC V5Z 4S6, Canada.

Abstract

Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its â¼20-megabase genome, which contains â¼6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference15 articles.

1. Cryptococcus neoformans 1998

2. A Yeast under Cover: the Capsule of Cryptococcus neoformans

3. Melanin and virulence in Cryptococcus neoformans

4. Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae

5. J. A. Fraser et al . in preparation.

Cited by 645 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pan-omics-based characterization and prediction of highly multidrug-adapted strains from an outbreak fungal species complex;The Innovation;2024-09

2. Elucidation of SSR polymorphism in human pathogenic fungi Cryptococcus neoformans with focus on isolate-specific marker generation and genetic diversity assessment;Biologia;2024-08-14

3. Life cycle and mating compatibility in the Japanese white jelly mushroom, <i>Tremella yokohamensis</i>;Mycoscience;2024-06-29

4. Comparative genomics of the closely related fungal genera Cryptococcus and Kwoniella reveals karyotype dynamics and suggests evolutionary mechanisms of pathogenesis;PLOS Biology;2024-06-06

5. Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts;Science;2024-04-26