Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling-Reference-Cited by-同舟云学术

Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling

Published:2013-11-08 Issue:6159 Volume:342 Page:734-737
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kasahara Atsuko¹,Cipolat Sara²,Chen Yun³,Dorn Gerald W.³,Scorrano Luca²⁴

Affiliation:

1. Department of Cell Physiology and Metabolism, University of Geneva, 1206 Geneva, Switzerland.

2. Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padova, Italy.

3. Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO, USA.

4. Department of Biology, University of Padua, 35121 Padova, Italy.

Abstract

Mitochondrial Fusion and Heart Development The role of mitochondria in fueling homeostatic cell processes is well appreciated, but whether and how they influence cell differentiation is much less clear. Using in vivo embryonic mouse models and mouse embryonic stem cell cultures, Kasahara et al. (p. 734 , published online 3 October) found that an intact mitochondrial fusion pathway was essential for the cellular signaling that drives mesodermal cell differentiation into cardiomyocytes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference27 articles.

1. The Pathophysiology of Mitochondrial Cell Death

2. Mitochondrial Function Controls Proliferation and Early Differentiation Potential of Embryonic Stem Cells

3. Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells

4. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy

5. Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum

Cited by 311 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Differentiation activates mitochondrial OPA1 processing in myoblast cell lines;Mitochondrion;2024-09

2. The regulation of ion homeostasis across multiple organelles;SCIENTIA SINICA Vitae;2024-08-01

3. USP7/NOTCH1: A potential therapeutic mechanism for cardiac diseases;International Journal of Cardiology;2024-08

4. DHODH Alleviates Heart Failure via the Modulation of CoQ-Related Ferroptotic Inhibition;Frontiers in Bioscience-Landmark;2024-07-24

5. Polystyrene nanoplastics exert cardiotoxicity through the Notch and Wnt pathways in zebrafish (Danio rerio);Science of The Total Environment;2024-07