Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer’s Disease Risk Factors in Yeast

Author:

Treusch Sebastian12,Hamamichi Shusei13,Goodman Jessica L.1,Matlack Kent E. S.12,Chung Chee Yeun1,Baru Valeriya12,Shulman Joshua M.45,Parrado Antonio6,Bevis Brooke J.1,Valastyan Julie S.12,Han Haesun1,Lindhagen-Persson Malin7,Reiman Eric M.89,Evans Denis A.10,Bennett David A.11,Olofsson Anders7,DeJager Philip L.45,Tanzi Rudolph E.6,Caldwell Kim A.3,Caldwell Guy A.3,Lindquist Susan12

Affiliation:

1. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

2. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.

4. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

5. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.

6. Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

7. Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden.

8. Neurogenomics Division, Translational Genomics Research Institute and Arizona Alzheimer’s Consortium, Phoenix, AZ 85004, USA.

9. Banner Alzheimer’s Institute and Department of Psychiatry, University of Arizona, Phoenix, AZ 85006, USA.

10. Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

11. Rush Alzheimer’s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

Abstract

The use of yeast as a model organism reveals cellular factors involved in beta-amyloid toxicity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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