Affiliation:
1. W. M. Keck Center for Integrative Neuroscience, University of California, San Francisco, CA, USA.
Abstract
The mammalian auditory cortex normally undergoes rapid and progressive functional maturation. Here we show that rearing infant rat pups in continuous, moderate-level noise delayed the emergence of adultlike topographic representational order and the refinement of response selectivity in the primary auditory cortex (A1) long beyond normal developmental benchmarks. When those noise-reared adult rats were subsequently exposed to a pulsed pure-tone stimulus, A1 rapidly reorganized, demonstrating that exposure-driven plasticity characteristic of the critical period was still ongoing. These results demonstrate that A1 organization is shaped by a young animal's exposure to salient, structured acoustic inputs—and implicate noise as a risk factor for abnormal child development.
Publisher
American Association for the Advancement of Science (AAAS)
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