A Heat-Sensitive TRP Channel Expressed in Keratinocytes-Reference-Cited by-同舟云学术

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

Published:2002-06-14 Issue:5575 Volume:296 Page:2046-2049
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Peier Andrea M.¹,Reeve Alison J.²,Andersson David A.²,Moqrich Aziz³,Earley Taryn J.³,Hergarden Anne C.¹,Story Gina M.³,Colley Sian²,Hogenesch John B.¹,McIntyre Peter²,Bevan Stuart²,Patapoutian Ardem¹³

Affiliation:

1. Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.

2. Novartis Institute for Medical Sciences, London WC1E 6BN, UK.

3. Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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