Functional Role of Aspartic Acid-27 in Dihydrofolate Reductase Revealed by Mutagenesis
Author:
Affiliation:
1. Agouron Institute, La Jolla CA 92037
2. Department of Chemistry, University of California, San Diego, La Jolla 92093.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference42 articles.
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2. BACCANARI, D.P., EFFECT OF A SINGLE AMINO-ACID SUBSTITUTION ON ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE CATALYSIS AND LIGAND-BINDING, JOURNAL OF BIOLOGICAL CHEMISTRY 256: 1738 (1981).
3. BLAKLEY, R.L., FOLATES PTERINS 1: 191 (1984).
4. BOLIN, J.T., CRYSTAL-STRUCTURES OF ESCHERICHIA-COLI AND LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE REFINED AT 1.7 A RESOLUTION .1. GENERAL FEATURES AND BINDING OF METHOTREXATE, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 3650 (1982).
5. CAYLEY, P.J., KINETICS OF SUBSTRATE, COENZYME, AND INHIBITOR BINDING TO ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE, BIOCHEMISTRY 20: 874 (1981).
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