Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions-Reference-Cited by-同舟云学术

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

Published:2014-04-11 Issue:6180 Volume:344 Page:189-193
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Orthwein Alexandre¹,Fradet-Turcotte Amélie¹,Noordermeer Sylvie M.¹,Canny Marella D.¹,Brun Catherine M.¹,Strecker Jonathan¹²,Escribano-Diaz Cristina¹,Durocher Daniel¹²

Affiliation:

1. The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

2. Department of Molecular Genetics, University of Toronto, Ontario M5S 3E1, Canada.

Abstract

Shutting Down Repair to Protect Cells repair DNA double-strand breaks (DSBs) by halting the cell cycle and activating the machinery involved in mending the breaks. However, during mitosis neither the DNA damage checkpoint nor DSB repair occur, apparently leaving the cell extremely vulnerable to DSBs. Orthwein et al. (p. 189 , published online 20 March) found that the DSB response was blocked by the phosphorylation of two crucial repair factors, RNF8 and PB531, preventing their recruitment to the site of damage. Restoring DSB repair during mitosis caused end-to-end chromosome fusions, which are catastrophic for chromosome segregation and normal cell division, explaining why the repair machinery is shut down during cell division.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

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4. DNA damage signaling in response to double-strand breaks during mitosis

5. A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

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