Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling-Reference-Cited by-同舟云学术

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

Published:2011-06-10 Issue:6035 Volume:332 Page:1322-1326
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yu Yonghao¹,Yoon Sang-Oh¹,Poulogiannis George²,Yang Qian¹³,Ma Xiaoju Max¹,Villén Judit¹,Kubica Neil¹,Hoffman Gregory R.¹,Cantley Lewis C.²,Gygi Steven P.¹,Blenis John¹

Affiliation:

1. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

2. Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

3. Harvard School of Dental Medicine, Boston, MA 02115, USA.

Abstract

A search for substrates of a growth-promoting kinase revealed a regulatory feedback loop involved in tumor suppression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference16 articles.

1. New Insights into mTOR Signaling: mTORC2 and Beyond

2. Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance, and cancer therapy

3. Molecular mechanisms of mTOR-mediated translational control

4. Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

5. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer;Carracedo A.;J. Clin. Invest.,2008

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