Affiliation:
1. Department of Infectology, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
Abstract
DNA-less Evolution
Prions are proteinaceous infectious elements involved in a variety of neurodegenerative diseases, including scrapie in sheep and so-called mad cow disease in cattle. Now
Li
et al.
(p.
869
, published online 31 December) show that, when propagated in tissue culture cells, cloned prion populations become diverse by mutational events and can undergo selective amplification. Thus, even though devoid of a coding genome, prions, when propagated under a particular selection regime, can be subject to rapid evolution.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
356 articles.
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