Spatial Coordination of Spindle Assembly by Chromosome-Mediated Signaling Gradients-Reference-Cited by-同舟云学术

Spatial Coordination of Spindle Assembly by Chromosome-Mediated Signaling Gradients

Published:2005-08-26 Issue:5739 Volume:309 Page:1373-1376
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Caudron Maïwen¹²,Bunt Gertrude¹²,Bastiaens Philippe¹²,Karsenti Eric¹²

Affiliation:

1. Cell Biology and Biophysics Department, European Molecular Biology Laboratory (EMBL), EMBL, 69117 Heidelberg, Germany.

2. Max-Planck-Institut für Experimentelle Medizin, 37075 Göttingen, Germany.

Abstract

During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-β. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Beyond self-assembly: From microtubules to morphogenesis

2. Early stages of spindle formation and independence of chromosome and microtubule cycles inHaemanthus endosperm

3. Aster-free spindle poles in insect spermatocytes: evidence for chromosome-induced spindle formation?

4. Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein.

5. Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase.

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