A conserved NAD + binding pocket that regulates protein-protein interactions during aging

Author:

Li Jun1ORCID,Bonkowski Michael S.1,Moniot Sébastien2,Zhang Dapeng3,Hubbard Basil P.1,Ling Alvin J. Y.1ORCID,Rajman Luis A.1ORCID,Qin Bo4,Lou Zhenkun4,Gorbunova Vera5,Aravind L.3,Steegborn Clemens2,Sinclair David A.16ORCID

Affiliation:

1. Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Biochemistry, University of Bayreuth, 95440 Bayreuth, Germany.

3. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

4. Division of Oncology Research, Department of Oncology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.

5. Division of Biology, 434 Hutchinson Hall, River Campus, University of Rochester, Rochester, NY 14627, USA.

6. Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia.

Abstract

NAD + can influence DNA repair by modulating protein interactions.

Funder

National Institute on Aging

National Institute of Diabetes and Digestive and Kidney Diseases

Glenn Foundation for Medical Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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