Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma-Reference-Cited by-同舟云学术

Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma

Published:2012-01-06 Issue:6064 Volume:335 Page:104-108
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Modi Badri G.¹,Neustadter Jason¹,Binda Elisa²³,Lewis Julia¹,Filler Renata B.¹,Roberts Scott J.¹,Kwong Bernice Y.¹,Reddy Swapna¹,Overton John D.⁴,Galan Anjela¹,Tigelaar Robert¹,Cai Lining⁵,Fu Peter⁶,Shlomchik Mark⁷,Kaplan Daniel H.⁸⁹,Hayday Adrian²³,Girardi Michael¹

Affiliation:

1. Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA.

2. Peter Gorer Department of Immunobiology, King’s College, the Comprehensive Biomedical Research Centre of Guy’s and St. Thomas’ Hospitals, London SE1 9RT, UK.

3. London Research Institute, Cancer Research UK (CRUK), London WC2A, UK.

4. Department of Genetics and Yale Center for Genome Analysis, Yale University School of Medicine, New Haven, CT 06520, USA.

5. Biotranex, Monmouth Junction, NJ 08852, USA.

6. National Center for Toxicological Research, United States Food and Drug Administration (FDA), Jefferson, AR 72079, USA.

7. Department of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

8. Department of Dermatology, University of Minnesota, Minneapolis, MN 55455, USA.

9. Department of Immunobiology, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

The Dark Side of Langerhans Cells Several immune cell populations reside in the skin and are thought to provide a protective barrier against infections and to act as sentinels against malignant transformation. However, studies in mice that lack Langerhans cells, a subset of dendritic cells, have suggested that these cells may actually promote tumorigenesis. Using a mouse model of squamous cell carcinoma, Modi et al. (p. 104 ) now reveal how Langerhans cells may promote the transformation of skin epithelial cells. In response to the carcinogen 7,12-dimethylbenz[α]anthracene (DMBA), Langerhans cells increased their expression of the cytochrome P-450 enzyme CYP1B1, which can metabolize DMBA to the mutagenic DMBA- trans -3,4-diol. Thus, besides their functions in regulating the adaptive immune response, Langerhans cells may participate in the metabolism of environmental carcinogens.

Funder

National Cancer Institute

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

http://www.sciencemag.org/content/335/6064/104.full.pdf

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