Malaria infection and severe disease risks in Africa-Reference-Cited by-同舟云学术

Malaria infection and severe disease risks in Africa

Published:2021-08-20 Issue:6557 Volume:373 Page:926-931
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Paton Robert S.¹^ORCID,Kamau Alice²³^ORCID,Akech Samuel²^ORCID,Agweyu Ambrose²⁴^ORCID,Ogero Morris²^ORCID,Mwandawiro Charles⁵,Mturi Neema⁶^ORCID,Mohammed Shebe⁶^ORCID,Mpimbaza Arthur⁷^ORCID,Kariuki Simon⁸^ORCID,Otieno Nancy A.⁸^ORCID,Nyawanda Bryan O.⁸^ORCID,Mohamed Amina F.⁴⁹^ORCID,Mtove George¹⁰,Reyburn Hugh⁹^ORCID,Gupta Sunetra¹^ORCID,Bejon Philip³⁶,Lourenço José¹^ORCID,Snow Robert W.²³

Affiliation:

1. Department of Zoology, University of Oxford, Oxford, UK.

2. Kenya Medical Research Institute (KEMRI)–Wellcome Trust Research Programme, Nairobi, Kenya.

3. Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

4. Kilimanjaro Christian Medical Centre/Joint Malaria Programme, Moshi, Tanzania.

5. Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.

6. Kenya Medical Research Institute (KEMRI)–Wellcome Trust Research Programme, Kilifi, Kenya.

7. Child Health and Development Centre, Makerere University, College of Health Sciences, Kampala, Uganda.

8. Kenya Medical Research Institute (KEMRI)–Centre for Global Health Research, Kisumu, Kenya.

9. London School of Hygiene and Tropical Medicine, London, UK.

10. National Institute for Medical Research, Amani Research Centre, Muheza, Tanzania.

Abstract

Childhood malaria Understanding how changes in community parasite prevalence alter the rate and age distribution of severe malaria is essential for optimizing control efforts. Paton et al . assessed the incidence of pediatric severe malaria admissions from 13 hospitals in East Africa from 2006 to 2020 (see the Perspective by Taylor and Slutsker). Each 25% increase in community parasite prevalence shifted hospital admissions toward younger children. Low rates of lifetime infections appeared to confer some immunity to severe malaria in very young children. Children under the age of 5 years thus need to remain a focus of disease prevention for malaria control. —CA

Funder

Centers for Disease Control and Prevention

Wellcome

European Commission

Deltas Africa Initiative

FCDO/MRC/NIHR/Wellcome Trust Joint Global Health Trials Scheme

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference63 articles.

1. Global malaria mortality between 1980 and 2010: a systematic analysis