Mouse models of acute and chronic hepacivirus infection-Reference-Cited by-全球学者库

Mouse models of acute and chronic hepacivirus infection

Published:2017-07-14 Issue:6347 Volume:357 Page:204-208
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Billerbeck Eva¹^ORCID,Wolfisberg Raphael²^ORCID,Fahnøe Ulrik²^ORCID,Xiao Jing W.¹^ORCID,Quirk Corrine¹,Luna Joseph M.¹^ORCID,Cullen John M.³^ORCID,Hartlage Alex S.⁴^ORCID,Chiriboga Luis⁵^ORCID,Ghoshal Kalpana⁶^ORCID,Lipkin W. Ian⁷^ORCID,Bukh Jens²^ORCID,Scheel Troels K. H.¹²^ORCID,Kapoor Amit⁴,Rice Charles M.¹^ORCID

Affiliation:

1. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.

2. Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

3. College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

4. Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital and Department of Pediatrics, Ohio State University, Columbus, OH, USA.

5. Department of Pathology, New York University Medical Center, New York, NY, USA.

6. Department of Pathology, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.

7. Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.

Abstract

New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impeded by the absence of mouse models suitable for studying the immune response to HCV. Billerbeck et al. found that a HCV-related virus isolated from New York City rats produces an infection in laboratory mice that shares several immunological features with human infections (see the Perspective by Klenerman and Barnes). Their initial analyses of the infected mice revealed that acute clearance of the virus was dependent on T cells but not on natural killer cells. Science , this issue p. 204 ; see also p. 129

Funder

National Institutes of Health

NIH Office of the Director

Greenberg Medical Research Institute

Starr Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

1. The ins and outs of hepatitis C virus entry and assembly

2. Animal Models for Hepatitis C