Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

Author:

Castellano Brian M.12ORCID,Thelen Ashley M.12ORCID,Moldavski Ofer12,Feltes McKenna3ORCID,van der Welle Reini E. N.12,Mydock-McGrane Laurel4ORCID,Jiang Xuntian3,van Eijkeren Robert J12ORCID,Davis Oliver B.12,Louie Sharon M.15ORCID,Perera Rushika M.6,Covey Douglas F.4ORCID,Nomura Daniel K.15,Ory Daniel S.3,Zoncu Roberto12ORCID

Affiliation:

1. Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.

2. The Paul F. Glenn Center for Aging Research at the University of California, Berkeley, Berkeley, CA 94720, USA.

3. Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

4. Department of Developmental Biology and Biochemistry, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA 94720, USA.

6. Department of Anatomy, Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

A cholesterol-mTORC1 axis may play a role in metabolic homeostasis in normal and disease states.

Funder

NIH

Pew-Stewart Scholarship for Cancer Research

Damon Runyon-Rachleff Innovation Award

Edward Mallinckrodt, Jr. Foundation

National Institutes of Health

Taylor Family Institute for Innovative Psychiatric Research

National Science Foundation

Howard Hughes Medical Institute Gilliam Fellow

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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