Genotype to Phenotype: A Complex Problem-Reference-Cited by-同舟云学术

Genotype to Phenotype: A Complex Problem

Published:2010-04-23 Issue:5977 Volume:328 Page:469-469
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dowell Robin D.¹,Ryan Owen²³⁴,Jansen An⁵,Cheung Doris²³⁴,Agarwala Sudeep⁵,Danford Timothy¹,Bernstein Douglas A.⁵,Rolfe P. Alexander¹,Heisler Lawrence E.²³⁴,Chin Brian⁵,Nislow Corey²³⁴,Giaever Guri³⁴⁶,Phillips Patrick C.⁷,Fink Gerald R.⁵⁸,Gifford David K.¹⁵⁸,Boone Charles²³⁴

Affiliation:

1. Computer Science and Artificial Intelligence Laboratory, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

2. Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

3. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada.

4. Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

5. Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

6. Department of Pharmacy University of Toronto, Toronto, ON M5S 3E1, Canada.

7. Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, OR 97403, USA.

8. Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

In yeast, the impact of gene knockouts depends on genetic background.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference6 articles.

1. Rare Variants Create Synthetic Genome-Wide Associations

2. Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome

3. Principles for the Buffering of Genetic Variation

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5. Functional profiling of the Saccharomyces cerevisiae genome

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