Affiliation:
1. Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus-Vienna-Biocenter 1, 1030 Vienna, Austria.
Abstract
Neuronal basis of lethargy in worms
How does the brain switch between wakefulness and sleep? Nichols
et al.
studied this question using brain-wide Ca2
+
imaging at single-neuron resolution in nematodes. By changing O
2
concentrations, they could rapidly switch the worms between behaviorally quiescent and active states. They observed a global quiescence brain state characterized by the systemic down-regulation of neuronal network dynamics. Signaling from O
2
sensory neurons rapidly evoked and maintained active network dynamics. Conversely, in the absence of such arousing cues, network dynamics converged into the quiescent mode.
Science
, this issue p.
eaam6851
Funder
Simons Foundation
European Research Council
Boehringer Ingelheim Fonds
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
137 articles.
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