Nuclear magnetic resonance detection and spectroscopy of single proteins using quantum logic

Author:

Lovchinsky I.1,Sushkov A. O.12,Urbach E.1,de Leon N. P.12,Choi S.1,De Greve K.1,Evans R.1,Gertner R.2,Bersin E.1,Müller C.3,McGuinness L.3,Jelezko F.3,Walsworth R. L.145,Park H.1256,Lukin M. D.1

Affiliation:

1. Department of Physics, Harvard University, Cambridge, MA 02138, USA.

2. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

3. Institute for Quantum Optics and Center for Integrated Quantum Science and Technology (IQST), Ulm University, D-89081, Ulm, Germany.

4. Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138, USA.

5. Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.

6. Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

Sensing single proteins with diamonds Nuclear magnetic resonance is a powerful technique for medical imaging and the structural analysis of materials, but is usually associated with large-volume samples. Lovchinsky et al. exploited the magnetic properties of a single spin associated with a defect in diamond and manipulated it with a quantum-logic protocol. They demonstrated the magnetic resonance detection and spectroscopy of multiple nuclear species within individual ubiquitin proteins attached to a specially treated diamond surface at room temperature. Science , this issue p. 836

Funder

Defense Advanced Research Projects Agency

NSF

Center for Ultracold Atoms

Army Research Office

National Security Science and Engineering Faculty

Gordon and Betty Moore Foundation

European Research Council

German Academic Exchange Service (DAAD)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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