Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis-Reference-Cited by-同舟云学术

Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

Published:2010-11-12 Issue:6006 Volume:330 Page:980-982
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Eisele Yvonne S.¹²,Obermüller Ulrike¹²,Heilbronner Götz¹²³,Baumann Frank¹²,Kaeser Stephan A.¹²,Wolburg Hartwig⁴,Walker Lary C.⁵,Staufenbiel Matthias⁶,Heikenwalder Mathias⁷,Jucker Mathias¹²

Affiliation:

1. Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

2. DZNE–German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany.

3. Graduate School for Cellular and Molecular Neuroscience, University of Tübingen, D-72074 Tübingen, Germany.

4. Department of Pathology, University of Tübingen, D-72076 Tübingen, Germany.

5. Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA.

6. Novartis Institutes for Biomedical Research, Neuroscience Discovery, CH-4056 Basel, Switzerland.

7. Department of Pathology, Institute for Neuropathology, University Hospital, CH-8091 Zürich, Switzerland.

Abstract

Infectious Amyloid? Patients with Alzheimer's disease have characteristic lesions in the brains associated with masses of polymerized protein called β-amyloid. Recently, evidence from mouse models of Alzheimer's disease shows that brain extracts containing β-amyloid can “infect” otherwise healthy animals when injected directly into their brains. Eisele et al. (p. 980 , published online 21 October; see the Perspective by

Kim and Holtzman

) extend these findings to show that when mice are injected in other parts of their bodies with similar brain extracts after several months, they also develop amyloidosis within their brains.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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