A Mutation in the C. elegans EXP-2 Potassium Channel That Alters Feeding Behavior-Reference-Cited by-同舟云学术

A Mutation in the C. elegans EXP-2 Potassium Channel That Alters Feeding Behavior

Published:1999-12-24 Issue:5449 Volume:286 Page:2501-2504
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Davis M. Wayne¹,Fleischhauer Richard²,Dent Joseph A.¹,Joho Rolf H.²,Avery Leon¹

Affiliation:

1. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390–9148, USA.

2. The Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390–9111, USA.

Abstract

The nematode pharynx has a potassium channel with unusual properties, which allows the muscles to repolarize quickly and with the proper delay. Here, the Caenorhabditis elegans exp-2 gene is shown to encode this channel. EXP-2 is a Kv-type (voltage-activated) potassium channel that has inward-rectifying properties resembling those of the structurally dissimilar human ether-à-go-go –related gene (HERG) channel. Null and gain-of-function mutations affect pharyngeal muscle excitability in ways that are consistent with the electrophysiological behavior of the channel, and thereby demonstrate a direct link between the kinetics of this unusual channel and behavior.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Byerly L., Masuda M. O., J. Physiol. (London) 288, 263 (1979).

2. Mutations in the Caenorhabditis elegans Na,K-ATPase alpha-subunit gene, eat-6, disrupt excitable cell function

3. Genetic analysis of defecation in Caenorhabditis elegans.

4. Worms were cultured and handled as described by J. Sulston and J. Hodgkin [in The Nematode Caenorhabditis elegans W. B. Wood Ed. (Cold Spring Harbor Laboratory Press Plainview NY 1988) pp. 587–606] with minor modifications as described [

5. The genetics of feeding in Caenorhabditis elegans.

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