Immunoglobulin-Domain Proteins Required for Maintenance of Ventral Nerve Cord Organization-Reference-Cited by-同舟云学术

Immunoglobulin-Domain Proteins Required for Maintenance of Ventral Nerve Cord Organization

Published:2002-01-25 Issue:5555 Volume:295 Page:686-690
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Aurelio Oscar¹,Hall David H.²,Hobert Oliver¹

Affiliation:

1. Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

2. Center for C. elegans Anatomy, Albert Einstein College of Medicine, Department of Neuroscience, Bronx, NY 10461, USA.

Abstract

During development, neurons extend axons along defined routes to specific target cells. We show that additional mechanisms ensure that axons maintain their correct positioning in defined axonal tracts. After termination of axonal outgrowth and target recognition, axons in the ventral nerve cord (VNC) of Caenorhabditis elegans require the presence of a specific VNC neuron, PVT, to maintain their correct positioning in the left and right fascicles of the VNC. PVT may exert its stabilizing function by the temporally tightly controlled secretion of 2-immunoglobulin (Ig)–domain proteins encoded by the zig genes. Dedicated axon maintenance mechanisms may be widely used to ensure the preservation of functional neuronal circuitries.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

1. R. M. Durbin thesis University of Cambridge Cambridge UK (1987).

2. In their electron microscopical reconstruction of the nervous system White et al. had lost the tracking of the PVT axon in the posterior half of the animal (18 19). Using several independent gfp reporters we could show that the axon of PVT extends into the nerve ring. Another update to the White et al. report (18) is Durbin's finding that PVPR and not PVPL extends along the left side of the VNC (1).

3. Neuroglia and Pioneer Neurons Express UNC-6 to Provide Global and Local Netrin Cues for Guiding Migrations in C. elegans

4. Role of netrin UNC-6 in patterning the longitudinal nerves ofCaenorhabditis elegans

5. P. Sonderegger Ed. Ig Superfamily Molecules in the Nervous System (Harwood Academic Amsterdam 1998).

Cited by 108 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nematode Extracellular Protein Interactome Expands Connections between Signaling Pathways;2024-07-08

2. The outer kinetochore components KNL-1 and Ndc80 complex regulate axon and neuronal cell body positioning in the C. elegans nervous system;Molecular Biology of the Cell;2024-06-01

3. Dendrite morphogenesis in Caenorhabditis elegans;GENETICS;2024-05-24

4. The Outer Kinetochore Proteins KNL-1 and Ndc80 complex are Required to Pattern the Central Nervous System;2024-03-27

5. Functions ofC. elegansneurons from synaptic connectivity;2024-03-13