Genome Sequence Diversity and Clues to the Evolution of Variola (Smallpox) Virus

Author:

Esposito Joseph J.1234,Sammons Scott A.1234,Frace A. Michael1234,Osborne John D.1234,Olsen-Rasmussen Melissa1234,Zhang Ming1234,Govil Dhwani1234,Damon Inger K.1234,Kline Richard1234,Laker Miriam1234,Li Yu1234,Smith Geoffrey L.1234,Meyer Hermann1234,LeDuc James W.1234,Wohlhueter Robert M.1234

Affiliation:

1. Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

2. Poxvirus and Rabies Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

3. Imperial College London, St. Mary's Campus, London, W2 1PG, UK.

4. Bundeswehr Institute of Microbiology, Munich, Germany 80937.

Abstract

Comparative genomics of 45 epidemiologically varied variola virus isolates from the past 30 years of the smallpox era indicate low sequence diversity, suggesting that there is probably little difference in the isolates' functional gene content. Phylogenetic clustering inferred three clades coincident with their geographical origin and case-fatality rate; the latter implicated putative proteins that mediate viral virulence differences. Analysis of the viral linear DNA genome suggests that its evolution involved direct descent and DNA end-region recombination events. Knowing the sequences will help understand the viral proteome and improve diagnostic test precision, therapeutics, and systems for their assessment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. Smallpox and Its Eradication 1988

2. Resolution WHA 55.15 2002

3. World Health Organization, Wkly. Epidemiol. Rec.74, 188 (1999).

4. World Health Organization, Wkly. Epidemiol. Rec.77, 34 (2002).

5. Smallpox as a Biological Weapon

Cited by 167 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3