Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks-Reference-Cited by-同舟云学术

Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks

Published:2021-06-04 Issue:6546 Volume:372 Page:1068-1073
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pederick Daniel T.¹^ORCID,Lui Jan H.¹^ORCID,Gingrich Ellen C.¹²^ORCID,Xu Chuanyun¹,Wagner Mark J.¹^ORCID,Liu Yuanyuan³,He Zhigang³^ORCID,Quake Stephen R.⁴⁵^ORCID,Luo Liqun¹^ORCID

Affiliation:

1. Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.

2. Neurosciences Graduate Program, Stanford University, Stanford, CA, USA.

3. F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA.

4. Departments of Bioengineering and Applied Physics, Stanford University, Stanford, CA, USA.

5. Chan Zuckerberg Biohub, Stanford, CA, USA.

Abstract

Keeping brain development untangled Brain circuits established during development can be overlapping or parallel as needed. Pederick et al. analyzed how parallel circuits in the mouse medial and lateral hippocampus develop without getting tangled up. Regulated expression of the cell surface molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) keeps confusion at bay. Together, these factors act as a membrane-bound ligand-receptor pair with repulsive outcomes, and they are able to destabilize a nascent but incorrect axon-target interaction. Individually, they each mediate homophilic attraction as axons search for their favored targets. Science, abg1774, this issue p. 1068

Funder

National Institutes of Health

Howard Hughes Medical Institute

American Australian Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.

1. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat

2. Loss of Recent Memory After Bilateral Hippocampal Lesions

3. THE MEDIAL TEMPORAL LOBE