Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin-Reference-Cited by-同舟云学术

Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin

Published:2013-10-25 Issue:6157 Volume:342 Page:441-446
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rowe Ashlee H.¹,Xiao Yucheng²,Rowe Matthew P.³,Cummins Theodore R.²,Zakon Harold H.¹⁴

Affiliation:

1. Section of Neurobiology, The University of Texas at Austin, Austin, TX 78712, USA.

2. Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

3. Department of Biological Sciences, Sam Houston State University, Huntsville, TX 77341, USA.

4. Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, USA.

Abstract

Bite Me! As unpleasant as it is, pain serves a purpose, to alert the body to potential damage. This protective function may explain why few predators have evolved resistance to the painful venoms used as a defense by their prey. The grasshopper mouse, however, is insensitive to one of the most painful stings in the animal kingdom—that of the bark scorpion. Rowe et al. (p. 441 ; see the Perspective by

Lewin

) now show that grasshopper mice use the toxins present in the scorpion venom to block voltage-gated pain transmission, temporarily reducing their sensitivity to nonvenom-induced pain. Thus, grasshopper mice use the scorpion's painful defense to their advantage and have evolved a mechanism that allows for reduction of pain sensitivity only when it is needed.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. An SCN9A channelopathy causes congenital inability to experience pain

2. J. O. Schmidt in Insect Defenses: Adaptive Mechanisms and Strategies of Prey and Predators D. L. Evans Ed. (State University of New York Press Albany NY 1990) pp. 383–417.

3. Envenomation by the Scorpion Centruroides Sculpturatus

4. V. Fet G. Lowe in Catalog of the Scorpions of the World (1758-1998) V. Fet W. D. Sissom G. Lowe M. E. Braunwalder Eds. (New York Entomological Society New York 2000) vol. 1 pp. 54–286.

5. Scorpion Envenomations in Young Children in Central Arizona

Cited by 113 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Analgesic potential of voltage gated sodium channel modulators for the management of pain;Current Opinion in Pharmacology;2024-04

2. A plethora of rodents: Rattlesnake predators generate unanticipated patterns of venom resistance in a grassland ecosystem;Toxicon: X;2024-03

3. Incorporating evolution into neuroscience teaching;Frontiers in Education;2023-11-10

4. The Diverse Mechanisms that Animals Use to Resist Toxins;Annual Review of Ecology, Evolution, and Systematics;2023-11-02

5. Machine learning study of the extended drug–target interaction network informed by pain related voltage-gated sodium channels;Pain;2023-10-18