CDK4 and CDK6 kinases: From basic science to cancer therapy-Reference-Cited by-同舟云学术

CDK4 and CDK6 kinases: From basic science to cancer therapy

Published:2022-01-14 Issue:6577 Volume:375 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fassl Anne¹^ORCID,Geng Yan¹,Sicinski Piotr¹^ORCID

Affiliation:

1. Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA.

Abstract

Targeting cyclin-dependent kinasesCyclin-dependent kinases (CDKs), in complex with their cyclin partners, modulate the transition through phases of the cell division cycle. Cyclin D–CDK complexes are important in cancer progression, especially for certain types of breast cancer. Fasslet al. discuss advances in understanding the biology of cyclin D–CDK complexes that have led to new concepts about how drugs that target these complexes induce cancer cell cytostasis and suggest possible combinations to widen the types of cancer that can be treated. They also discuss progress in overcoming resistance to cyclin D–CDK inhibitors and their possible application to diseases beyond cancer. —GKA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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