Allosteric Mechanisms of Signal Transduction-Reference-Cited by-同舟云学术

Allosteric Mechanisms of Signal Transduction

Published:2005-06-03 Issue:5727 Volume:308 Page:1424-1428
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Changeux Jean-Pierre¹²,Edelstein Stuart J.¹²

Affiliation:

1. Receptors and Cognition, Institut Pasteur, 75724 Paris Cedex 15, France.

2. Department of Biochemistry, University of Geneva, CH-1211 Geneva 4, Switzerland.

Abstract

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. J.-P. Changeux, Cold Spring Harbor Symp. Quant. Biol.26, 313 (1961).

2. D. E. Koshland Jr., J. Cell. Comp. Physiol.54, 245 (1959).

3. Allosteric proteins and cellular control systems

4. On the nature of allosteric transitions: A plausible model

5. Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*

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