Affiliation:
1. Division of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Abstract
Effective communication across brain areas requires distributed neuronal networks to dynamically synchronize or decouple their ongoing activity. GABA
ergic
interneurons lock ensembles to network oscillations, but there remain questions regarding how synchrony is actively disengaged to allow for new communication partners. We recorded the activity of identified interneurons in the CA1 hippocampus of awake mice. Neurogliaform cells (NGFCs)—which provide GABA
ergic
inhibition to distal dendrites of pyramidal cells—strongly coupled their firing to those gamma oscillations synchronizing local networks with cortical inputs. Rather than strengthening such synchrony, action potentials of NGFCs decoupled pyramidal cell activity from cortical gamma oscillations but did not reduce their firing nor affect local oscillations. Thus, NGFCs regulate information transfer by temporarily disengaging the synchrony without decreasing the activity of communicating networks.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
18 articles.
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