Differential Effects of Early Hippocampal Pathology on Episodic and Semantic Memory-Reference-Cited by-同舟云学术

Differential Effects of Early Hippocampal Pathology on Episodic and Semantic Memory

Published:1997-07-18 Issue:5324 Volume:277 Page:376-380
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Vargha-Khadem F.¹²³⁴,Gadian D. G.¹²³⁴,Watkins K. E.¹²³⁴,Connelly A.¹²³⁴,Van Paesschen W.¹²³⁴,Mishkin M.¹²³⁴

Affiliation:

1. F. Vargha-Khadem and K. E. Watkins, Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK.

2. D. G. Gadian and A. Connelly, Radiology and Physics Unit, Institute of Child Health, University College London Medical School, 30 Guilford Street, London WC1N 1EH, UK.

3. W. Van Paesschen, Radiology and Physics Unit, Institute of Child Health, University College London Medical School, 30 Guilford Street, London WC1N 1EH, UK, and Institute of Neurology, Queen Square, London WC1N 3BG, UK.

4. M. Mishkin, Laboratory of Neuropsychology, National Institutes of Mental Health, 49 Convent Drive, Bethesda, MD 20892–4415, USA.

Abstract

Global anterograde amnesia is described in three patients with brain injuries that occurred in one case at birth, in another by age 4, and in the third at age 9. Magnetic resonance techniques revealed bilateral hippocampal pathology in all three cases. Remarkably, despite their pronounced amnesia for the episodes of everyday life, all three patients attended mainstream schools and attained levels of speech and language competence, literacy, and factual knowledge that are within the low average to average range. The findings provide support for the view that the episodic and semantic components of cognitive memory are partly dissociable, with only the episodic component being fully dependent on the hippocampus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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