PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair-Reference-Cited by-同舟云学术

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

Published:2015-01-09 Issue:6218 Volume:347 Page:185-188
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ochi Takashi¹,Blackford Andrew N.²,Coates Julia²,Jhujh Satpal²,Mehmood Shahid³,Tamura Naoka⁴,Travers Jon²,Wu Qian¹,Draviam Viji M.⁴,Robinson Carol V.³,Blundell Tom L.¹,Jackson Stephen P.¹²⁵

Affiliation:

1. Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

2. Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

3. Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK.

4. Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.

5. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

Abstract

A factor for repairing broken DNA Unprogrammed DNA double-strand breaks are extremely dangerous for genomic stability. Nonhomologous end-joining (NHEJ) repair systems are present in all domains of life and help deal with these potentially lethal lesions. Ochi et al. have discovered a new factor involved in NHEJ by searching for proteins with structural similarities to known NHEJ proteins. Specifically, PAXX, a paralog of XRCC1 and XLF, interacts with a key repair pathway protein, Ku, and helps promote ligation of the broken DNA. Science , this issue p. 185

Funder

Wellcome Trust

European Research Council

European Community Seventh Framework Programme

Cancer Research UK (CRUK)

CRUK

CRUK Career Development Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.