Total synthesis of bryostatin 3

Author:

Trost Barry M.1ORCID,Wang Youliang1ORCID,Buckl Andreas K.1ORCID,Huang Zhongxing1ORCID,Nguyen Minh H.1ORCID,Kuzmina Olesya1

Affiliation:

1. Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.

Abstract

Stitching alkynes into bryostatin 3 The bryostatin family of marine natural products has been explored for a wide variety of pharmaceutical applications but remains challenging to source. The general structure comprises a macrocycle that contains three smaller, six-membered rings. Bryostatin 3 is distinguished by the added complexity of a fourth, fused lactone ring. Trost et al. report a convergent synthesis of this complex molecule, taking advantage of alkyne coupling reactions to stitch together three main fragments and asymmetric dihydroxylation and propargylation reactions to set stereochemistry. Science , this issue p. 1007

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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