Affiliation:
1. Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
Abstract
Stitching alkynes into bryostatin 3
The bryostatin family of marine natural products has been explored for a wide variety of pharmaceutical applications but remains challenging to source. The general structure comprises a macrocycle that contains three smaller, six-membered rings. Bryostatin 3 is distinguished by the added complexity of a fourth, fused lactone ring. Trost
et al.
report a convergent synthesis of this complex molecule, taking advantage of alkyne coupling reactions to stitch together three main fragments and asymmetric dihydroxylation and propargylation reactions to set stereochemistry.
Science
, this issue p.
1007
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
25 articles.
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