Probing Exchange Pathways in One-Dimensional Aggregates with Super-Resolution Microscopy

Author:

Albertazzi Lorenzo12,van der Zwaag Daan13,Leenders Christianus M. A.13,Fitzner Robert4,van der Hofstad Remco W.14,Meijer E. W.123

Affiliation:

1. Institute for Complex Molecular Systems, Eindhoven University of Technology, Post Office Box 513, 5600 MD Eindhoven, Netherlands.

2. Laboratory of Chemical Biology, Eindhoven University of Technology, Post Office Box 513, 5600 MD Eindhoven, Netherlands.

3. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Post Office Box 513, 5600 MD Eindhoven, Netherlands.

4. Department of Mathematics and Computer Science, Eindhoven University of Technology, Post Office Box 513, 5600 MD Eindhoven, Netherlands.

Abstract

Examining Supramolecular Exchange Microtubules are a natural example of a one-dimensional (1D) supramolecular structure. Synthetic examples of 1D fibrils often have monomers linked by weak noncovalent interactions that allow monomers to exchange in and out of the fibrils. Albertazzi et al. (p. 491 ) used a combination of super-resolution microscopy on individual fibrils and stochastic simulation to study monomer exchange in fibrils formed from stacked 1,3,5-benzenetricarboxamide motifs. Exchange did not require large-scale depolymerization and repolymerization, or reassembly of fragments, but proceeded through individual monomers exchanging homogeneously throughout the fibrils.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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