Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1

Author:

Delgado Ryan N.1234ORCID,Mansky Benjamin125ORCID,Ahanger Sajad Hamid126ORCID,Lu Changqing7,Andersen Rebecca E.128ORCID,Dou Yali9,Alvarez-Buylla Arturo12ORCID,Lim Daniel A.126ORCID

Affiliation:

1. Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.

2. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.

3. Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA 94143, USA.

4. Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

5. Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

6. San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.

7. Department of Human Anatomy, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, P.R. China.

8. Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

9. Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Sustaining stem cell identity Stem cells in the developing brain acquire identities according to their locations and the types of neurons they will generate. As the brain grows larger and more complex, these identities must be maintained. Delgado et al. found this positional identity to be sustained by an epigenetic memory system. A morphogen sets the stem cell's identity early in development, but the identity is sustained by epigenetics. Science , this issue p. 48

Funder

NIH Office of the Director

National Institute of General Medical Sciences

U.S. Department of Veterans Affairs

Shurl and Kay Curci Foundation

LoGlio Foundation

Hana Jabsheh Initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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