Functional Expression of a Mammalian Odorant Receptor-Reference-Cited by-同舟云学术

Functional Expression of a Mammalian Odorant Receptor

Published:1998-01-09 Issue:5348 Volume:279 Page:237-242
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhao Haiqing¹²³,Ivic Lidija¹²³,Otaki Joji M.¹²³,Hashimoto Mitsuhiro¹²³,Mikoshiba Katsuhiro¹²³,Firestein Stuart¹²³

Affiliation:

1. H. Zhao, Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA.

2. L. Ivic, J. M. Otaki, S. Firestein, Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

3. M. Hashimoto and K. Mikoshiba, Molecular Neurobiology Lab, Tsukuba Life Sciences Center, RIKEN, Tsukuba, Ibaraki 305, Japan.

Abstract

Candidate mammalian odorant receptors were first cloned some 6 years ago. The physiological function of these receptors in initiating transduction in olfactory receptor neurons remains to be established. Here, a recombinant adenovirus was used to drive expression of a particular receptor gene in an increased number of sensory neurons in the rat olfactory epithelium. Electrophysiological recording showed that increased expression of a single gene led to greater sensitivity to a small subset of odorants.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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5. We assume here from previous in situ hybridization studies that each of the approximately 1000 receptors is expressed in roughly 0.1% of the total olfactory neurons [

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